Preparation of Pyridine N-oxide Derivatives in Microreactor

Abstract

N-oxidations of different nitrogen-containing heterocyclic molecules are often applied for synthetic transformations in chemistry. The industrial implementation of classical batch oxidation processes are limited due to safety concerns derived from metal ion catalyzed decompositions. These restrictions and other safety concern issues can be minimized or even avoided by applying glass made microreactor setups for this transformation. The N-oxidation of different pyridine derivative, quinoline and isoquinoline is studied using two popular oxidizing reagents. The further transformation of pyridine derivatives is studied through the Polonovski rearrangement in microreactor.