The influence of glicerides oil phase on O/W nanoemulsion formation by pic method

Abstract

The aim of this work was preparation and characterization of nanoemulsions containing Caprylic/Capric Triglyceride, Caprylic/Capric/Linoleic Triglyceride and Caprylic/Capric/Succinic Triglyceride as the oil phase. Stable emulsion system was obtained by using Polisorbate 40 as emulsifier and n-buthanol as cosurfactant. The formulations were prepared by phase inversion composition method (PIC), one of the low energy emulsification method, by stepwise water addition to the mixture of oil and surfactant, at room temperature(25^oC).The mixture was stirred by using a magnetic stirrer. The type of the emulsions was confirmed by conductivity measurement. The particles size distribution was analyzed by Dynamic Light Scattering measurement technique using Zetasizer Nano ZS (Malvern Instruments, UK). Rheological studies of the systems were carried out using Brookfield Rheometer Model -R/SPlus. The obtained results showed that properties of the emulsions depend on kind of the oil phase. It was observed that the increase of oil phase polarity causes the increase of the particle size of internal phase.