Cyclodextrins as Dominant Chiral Selective Agents in the Capillary Separation Techniques

Authors

  • Zoltán Juvancz
    Affiliation
    Institute of Environmental Engineering, Óbuda University, H-1035 Budapest, 6 Doberdó Road, Hungary
  • Rita Bodáné-Kendrovics
    Affiliation
    Institute of Environmental Engineering, Óbuda University, H-1035 Budapest, 6 Doberdó Road, Hungary
  • Lajos Szente
    Affiliation
    Cyclolab Ltd., H-1525 Budapest, P.O.B. 435, Hungary
  • Dóra Maklári
    Affiliation
    Medical School Institute of Bioanalysis, University of Pécs, H-7624 Pécs, 1 Honvéd Street, Hungary
https://doi.org/10.3311/PPch.18067

Abstract

This review paper shows the dominant role of the cyclodextrins in the chiral separations using capillary columns (GC, SFC, CE). The cyclodextrins (CDs) have extremely broad chiral selectivity spectra because they have several different chiral recognition sites in various arrangements and various interaction modes. Their chiral selectivity features can further improve with their various substitutions. Their selectivities are moderate therefore they need high efficiency separations (capillary columns) for good chiral resolutions. The shape selectivity of cyclodextrins is also shown with non-chiral isomers too. The utility of the cyclodextrins is demonstrated with several examples based on the personal observations of authors and critical review of literature. The theoretical backgrounds of their chiral recognitions (e.g. H-bond interaction, inclusion, induced fit) are discussed in depth. This paper is not application oriented but is dealing with mostly on the physical and chemical background of separations using CDs.

Keywords:

chiral separations, cyclodextrins, interaction types, chiral recognitions mechanisms, structure-selectivity relationships

Citation data from Crossref and Scopus

Published Online

2021-08-26

How to Cite

Juvancz, Z., Bodáné-Kendrovics, R., Szente, L., Maklári, D. “Cyclodextrins as Dominant Chiral Selective Agents in the Capillary Separation Techniques”, Periodica Polytechnica Chemical Engineering, 65(4), pp. 580–594, 2021. https://doi.org/10.3311/PPch.18067

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Articles